Jurczak Lab Publications

For a full list of publication, click here.

  • Dysregulation of Lipid and Glucose Homeostasis in Hepatocyte-Specific SLC25A34 Knockout Mice
    by Nairita Roy on June 19, 2022 at 10:00 am

    Nonalcoholic fatty liver disease (NAFLD) is an epidemic affecting 30% of the US population. NAFLD is characterized by insulin resistance and by defective lipid metabolism and mitochondrial dysfunction in the liver. SLC25A34 is a major repressive target of miRNA-122, a miRNA that has a central role in NAFLD and liver cancer. However, little is known about the function of SLC25A34. To investigate SLC25A34 in vitro, mitochondrial respiration and bioenergetics were examined using hepatocytes...

  • Empagliflozin restores cardiac metabolic flexibility in diet-induced obese C57BL6/J mice
    by Bingxian Xie on June 9, 2022 at 10:00 am

    Sodium-glucose co-transporter type 2 (SGLT2) inhibitor therapy to treat type 2 diabetes unexpectedly reduced all-cause mortality and hospitalization due to heart failure in several large-scale clinical trials, and has since been shown to produce similar cardiovascular disease-protective effects in patients without diabetes. How SGLT2 inhibitor therapy improves cardiovascular disease outcomes remains incompletely understood. Metabolic flexibility refers to the ability of a cell or organ to adjust...

  • Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR
    by Ye Feng on May 7, 2022 at 10:00 am

    Diabetes and related metabolic syndrome are common metabolic disorders. Gestational diabetes mellitus (GDM) is rather prevalent in the clinic. Although most GDM resolves after therapeutic intervention and/or after delivery, the long-term health effect of GDM remains to be better understood. The constitutive androstane receptor (CAR), initially characterized as a xenobiotic receptor, was more recently proposed to be a therapeutic target for obesity and type 2 diabetes mellitus (T2DM). In this...

  • Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment
    by Dharendra Thapa on February 7, 2022 at 11:00 am

    Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibility, which is lost in obese and diabetic animals, has the potential to improve contractile function in the diabetic heart. Using an ex vivo approach, we examined whether short-term adropin treatment could enhance cardiac function in a mouse model of diet-induced...

  • Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries
    by Yuchen He on July 5, 2021 at 10:00 am

    Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood. In this study, we aim to identify the critical factors that dictate chondrocyte response to mechanical overloading, as well as to develop therapeutics that protect chondrocytes from mechanical injuries. Specifically,...